Dr. Miao’s research focuses on developing novel peptides that target malignant cells. His most significant scientific contributions involve theranostic approaches for malignant melanoma. His research team has developed a novel class of lactam-cyclized alpha-melanocyte stimulating hormone (α-MSH) peptides to target melanocortin-1 receptors (MC1Rs) for melanoma imaging and therapy. A recent publication in Science Translational Medicine was a first-in-man demonstration of MC1R as a molecular target for melanoma imaging. Dr. Miao’s novel technology has been funded by NIH and has been awarded three US patents.
psychiatric disorders including being one of the world’s leading experts on the development of automated image processing methods for accurate quantification of subtle and complex structural/functional changes in the brain. Dr. Shen has also made a major contribution to the development of novel image analysis tools to gain insights into early brain development.