Full List of Distinguished Investigators
2020 Distinguished Investigators










These techniques have allowed quantitative evaluation of all major knee joint tissues (e.g., superficial and deep layers of articular cartilage, calcified cartilage, subchondral bone, menisci, ligaments, tendons) and their components (e.g., proteoglycan through UTE T1rho mapping, collagen through UTE magnetization transfer imaging and modeling, as well as bound and free water fractions and contents through UTE bi-component analysis), thus a truly “whole-organ disease” approach for osteoarthritis (OA).





















area of SPECT imaging with an emphasis on quantitative imaging from theoretical analysis to hardware implementation. He has developed and validated analytic models of various collimators, but particularly pinhole and slit-slat. Dr. Metzler has developed calibration techniques for applying those models to real-world systems, including a novel helical-orbit pinhole system for addressing sampling completeness, an adaptive pinhole-collimator system for small-animal dynamic cardiac imaging, and the C-SPECT scanner, which is currently under development for dedicated human cardiac SPECT perfusion and dynamic imaging.




These biosensors require synthetic antibodies (aptamers) that change their conformation upon target binding. To create these reagents, Dr. Soh’s lab has developed many foundational technologies for high-throughput screening including the “Particle Display” technique and invented methods for controlling their thermodynamics and kinetics.



