- Multisite Clinical Center Common Fund Acute to Chronic Pain Signatures Program: Acute Peri-operative Pain (UM1) Clinical Trials Optional RFA-RM-18-034
- The purpose of this FOA is to support a Multisite Clinical Center to implement the enrollment and multimodal longitudinal assessment of a large cohort of acute peri-operative pain patients to identify a biosignature for resilience to and the transition from acute to chronic pain.
- Multisite Clinical Center Common Fund Acute to Chronic Pain Signatures Program: Acute Pain from Musculoskeletal Trauma (UM1) Clinical Trials Optional RFA-RM-18-033
- The purpose of this FOA is to support one Multisite Clinical Center (MCC) to implement the enrollment and multimodal longitudinal assessment of a large cohort of patients with acute pain from a musculoskeletal trauma to identify biosignatures for resilience to and/or the transition from acute to chronic pain.
- Clinical Coordination Center for Common Fund Acute to Chronic Pain Signatures (A2CPS) Program (U24) Clinical Trials Optional RFA-RM-18-035
- The purpose of this FOA is to identify and support a Clinical Coordination Center (CCC) for the Common Fund Acute to Chronic Pain Signatures (A2CPS) Program. The Clinical Coordinating Center is expected to serve as the hub for the Multisite Clinical Centers to support study design, efficiency, progress, and quality, and to coordinate and monitor study implementation across the clinical sites. The Clinical Coordinating Center will lead the consortium in developing and implementing standardized protocols, safety standards, staff training protocols, electronic health record (EHR) data standards, patient phenotyping and testing, and regulatory processes.
- Omics Data Generation Centers (ODGCs) for Common Fund Acute to Chronic Pain Signatures Program (U54) Clinical Trial Optional RFA-RM-18-032
- The purpose of this FOA is to support the establishment of center(s) that will use cutting edge technologies to perform omics analyses (e.g. metabolomic, lipidomic, proteomic, extracellular RNA) of body fluids collected by the Acute to Chronic Pain Signatures (A2CPS) consortium. The omics data generated, in concert with other patient assessments, will be used to identify biosignatures predictive of susceptibility or resilience to the development of chronic pain.
- Data Integration and Resource Center (DIRC) for Common Fund Acute to Chronic Pain Signatures Program (U54) Clinical Trial Optional RFA-RM-18-031
- The purpose of this FOA is to identify and support a Data Integration and Resource Center (DIRC) for the Common Fund Acute to Chronic Pain Signatures (A2CPS) Program. The overall programmatic goal of the DIRC is to integrate the efforts of all funded components of the A2CPS and serve as a community-wide nexus for protocols, data, assay and data standards, and other resources generated by the A2CPS Program.