Funding Opportunities now available for the NIH Common Fund’s Acute to Chronic Pain Signatures program
The NIH Common Fund’s Acute to Chronic Pain Signatures program aims to understand the biological characteristics underlying the transition from acute to chronic pain and what makes some people susceptible and others resilient to the development of chronic pain. A2CPS is part of the NIH-wide HEAL (Helping to End Addiction Long-term) Initiative, an aggressive, trans-NIH effort to speed scientific solutions to stem the national opioid public health crisis.
Summary: The A2CPS program will collect data from: (1) patients with acute pain associated with a surgical procedure and (2) patients with acute pain from a musculoskeletal trauma such as a broken bone. Neuroimaging, high-throughput biomedical measurements, sensory testing, and psychosocial assessments collected periodically after the acute pain event will form a comprehensive data set to help predict which patients will develop long-lasting chronic pain. The goal of these studies is to identify individual patient features that together, will provide clinically meaningful, predictive “signatures” of transition or resilience to chronic pain.
The NIH is inviting applications for five funding opportunities:
- Multisite Clinical Center Common Fund Acute to Chronic Pain Signatures Program: Acute Peri-operative Pain (UM1) Clinical Trials Optional RFA-RM-18-034
- The purpose of this FOA is to support a Multisite Clinical Center to implement the enrollment and multimodal longitudinal assessment of a large cohort of acute peri-operative pain patients to identify a biosignature for resilience to and the transition from acute to chronic pain.
- Multisite Clinical Center Common Fund Acute to Chronic Pain Signatures Program: Acute Pain from Musculoskeletal Trauma (UM1) Clinical Trials Optional RFA-RM-18-033
- The purpose of this FOA is to support one Multisite Clinical Center (MCC) to implement the enrollment and multimodal longitudinal assessment of a large cohort of patients with acute pain from a musculoskeletal trauma to identify biosignatures for resilience to and/or the transition from acute to chronic pain.
- Clinical Coordination Center for Common Fund Acute to Chronic Pain Signatures (A2CPS) Program (U24) Clinical Trials Optional RFA-RM-18-035
- The purpose of this FOA is to identify and support a Clinical Coordination Center (CCC) for the Common Fund Acute to Chronic Pain Signatures (A2CPS) Program. The Clinical Coordinating Center is expected to serve as the hub for the Multisite Clinical Centers to support study design, efficiency, progress, and quality, and to coordinate and monitor study implementation across the clinical sites. The Clinical Coordinating Center will lead the consortium in developing and implementing standardized protocols, safety standards, staff training protocols, electronic health record (EHR) data standards, patient phenotyping and testing, and regulatory processes.
- Omics Data Generation Centers (ODGCs) for Common Fund Acute to Chronic Pain Signatures Program (U54) Clinical Trial Optional RFA-RM-18-032
- The purpose of this FOA is to support the establishment of center(s) that will use cutting edge technologies to perform omics analyses (e.g. metabolomic, lipidomic, proteomic, extracellular RNA) of body fluids collected by the Acute to Chronic Pain Signatures (A2CPS) consortium. The omics data generated, in concert with other patient assessments, will be used to identify biosignatures predictive of susceptibility or resilience to the development of chronic pain.
- Data Integration and Resource Center (DIRC) for Common Fund Acute to Chronic Pain Signatures Program (U54) Clinical Trial Optional RFA-RM-18-031
- The purpose of this FOA is to identify and support a Data Integration and Resource Center (DIRC) for the Common Fund Acute to Chronic Pain Signatures (A2CPS) Program. The overall programmatic goal of the DIRC is to integrate the efforts of all funded components of the A2CPS and serve as a community-wide nexus for protocols, data, assay and data standards, and other resources generated by the A2CPS Program.
Applications are due October 24, 2018. An informational webinar will be held on September 6th, 2018 from 2-4 PM, EST.
Call-in toll number (US/Canada): 1-650-479-3208
Event number: 624 155 354
Event password: PainSig
National Institute on Neurological Disorders and Stroke (NINDS)
National Institute on Drug Abuse (NIDA)
The NIH Common Fund encourages collaboration and supports a series of exceptionally high impact, trans-NIH programs. These programs are supported by the Common Fund, and managed by the NIH Office of the Director in partnership with the various NIH Institutes, Centers, and Offices.
The National Institutes of Health (NIH) –“The Nation’s Medical Research Agency” – includes 27 Institutes and Centers and is a component of the U. S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments and cures for both common and rare diseases. For more information about the NIH and its programs, visit the NIH website.